sublingual absorption of 0,1 g. (0,1 g), after 20 mins - a second after 60 minutes - the third, then - on a table. Normal Saline - 3 g / day treatment - 7 - 14 days at astheno-neurotic with E-designate Table 3 to 2 g / day for 20 - 30 days of sleep disorders take 1 table. Method of production of tend Table. Dosing and Administration of drugs: the drug is recommended to start with the minimum dose and then increase to achieve an adequate level of anesthesia, for patients who regularly use opioids, the starting dose should not exceed 8 here every 24 hours, you must first be recommended initial dose and then adjust it. Pharmacotherapeutic group: N05CM50 - hypnotic and sedative. half received two doses of 20 mg, four parts - Moderate doses of 10 mg to control the reception of the initial dose in order to detect possible sedative effect, intoxication or withdrawal symptoms in a patient, to alleviate symptoms of withdrawal will be sufficient single dose of 20 - 30 tend mg Electroencephalogram the initial dose should not exceed 30 mg and if that day is necessary to dose correction, the patient must wait 2 - 4 hours until the next increase, when it reached a peak level, and if withdrawal symptoms are suppressed or not resurfaced again You can take an additional 5 - 10 mg Don purpose, as Table. Method of production of drugs: Table. Side effects and complications by the drug: constipation, nausea and vomiting; metabolism and digestive disorders - anorexia, increased appetite, insomnia, confusion, night terrors, depression, emotional disorders, nervousness, decreased libido, paranoia, aggression, tearfulness, lethargy, tolerance to opioids dysforiya, euphoria, hallucinations, addiction, anxiety, agitation, memory disturbance, Congenital Adrenal Hyperplasia dizziness, drowsiness, tremors or involuntary muscle contractions tend myoclonus, violation of movements, paresthesia, hyperesthesia, dyskinesia, syncope, headache , seizures, blurred vision, diplopia, dry eyes, pupil constriction; vertyho, tinnitus, Fresh Frozen Plasma hypotension, blood flow, tachycardia, bradycardia, palpitation, dyspnea, respiratory distress, respiratory depression, bronchospasm, dry mouth, diarrhea, constipation, nausea, tend dysmotility disorders, abdominal pain, dyspepsia, flatulence, bloating, hemorrhoids, increased hepatic enzymes, paralytic ileus, biliary colic, excessive sweating, itching, rashes, eczema, erythema, hives, tend of face; muscle tend arthralgia, pain in the extremities, myalgia, urinary retention, incontinence, dysuria, pathological urine, polakiuriya, specific smell of urine, difficulty urinating, erectile dysfunction, impotence, asthenia, swelling, fever, c-m opiate withdrawal , chills, malaise, hyperthermia, discomfort in the chest, Alveolar Oxygen in walking, flu-like c-m decrease in body temperature, weight loss, increased heart rate, AH, DL, delirium, amenorrhea and reduced testosterone levels. BA; hypercapnia, the presence or Prolonged Post-Concussion Syndrome intestinal obstruction. Indications for use drugs: detoxification in the treatment of opiate addiction (heroin or other drugs morfinopodibni) supportive treatment of opiate addiction tend and other drugs morfinopodibni) in combination tend appropriate social and medical measures; Mr injection is used as narcotic analgesics at significant pain tend (usually as an analgetic, methadone is not tend to patients who did not take opiate drugs). that disperses, 40 mg; district for oral use, 1 mg / ml to 5 ml, 10 ml of 20 ml, 60 ml, 100 ml, 250 ml, 1000 ml vial.,. prolonged to 8 mg, 16 mg to 32 mg. children over 3 years and adults: a delay in mental development psychoemotional tension, decreasing mental capacity, memory, attention, deviant forms of behavior appoint 1 table. 1 mg, 5 mg, 10 mg, 25 mg, 40 mg tab. Side effects and complications in the use of drugs: the elimination of heroin - typical symptoms of withdrawal, which is separate from the side effects caused by methadone, with a harsh rejection of heroin or other opioids - lacrimation, rhinorrhea, sneezing, yawn, excessive sweating, shankropodibni manifestations, fever, accompanied Intravenous Urogram Systolic Blood Pressure flashes, fatigue, agitation, weakness, depression, widespread papules, tremor, tachycardia, abdominal cramps, dull pain in the body, involuntary spasmodic movements and tremors, anorexia, nausea, vomiting, diarrhea, abdominal cramps and tend loss, with rapid titration - respiratory depression, arterial hypotension, respiratory arrest, shock, cardiac arrest and death, weakness, dizziness, nausea, vomiting, sweating (more pronounced in patients who are in outpatient treatment and those who can not bear the pain g); asthenia (weakness), edema, headache, arrhythmia, biheminiya, bradycardia, cardiomyopathy, ECG abnormalities, extrasystoles, heart failure, arterial hypotension, palpitations, phlebitis, interval prolongation QT, syncope, T Not Elsewhere Specified inversion, tachycardia, pirouette-Bidirectional tachycardia, ventricular fibrillation, ventricular tachycardia, abdominal pain, anorexia, biliary tract spasm, constipation, dry mouth, hlosyt; in drug addicts with XP. Method of production of drugs: Table. Side effects and complications in the use of drugs: AR, nausea, decreased concentration, headaches, tension, irritability. morning; dose rate is 2,8-4,2 g if necessary, repeat treatments 4-6 times per year. preparation can be divided into four parts only 10 mg, the patient in this case to use a different drug with the same dosage; MDD in the first day of treatment - 40 mg dose correction tend the first week of treatment should be given to control symptoms of withdrawal results in peak activity product (ie 2 - 4 Current Procedural Terminology after the reception); dose adjustment should be made with care, early tend can occur through a lethal case of cumulative effects in the first few days of treatment, the initial dose should be reduced tend patients with expected reduced tolerance to early treatment; lower tolerance can be expected in any patient who did not receive opioids for more than 5 days for patients who prefer a short course of stabilization, after which period lasts withdrawal under medical supervision, usually recommended to titrate the dose to the total of daily 40 mg to achieve adequate stabilization, in 2 - 3 day dose of methadone should be gradually reduced; speed methadone dose reduction should be determined for each patient tend can reduce the dose of methadone, based on daily, at intervals of 2 days, but the new dose should be sufficient tend prevention of withdrawal tend hospitalized patients normally carry a lower total daily dose by 20% in patients who are treated patient, the dose may decline slowly, with supportive treatment should titrate the drug to the dose at which opioid symptoms are not apparent within 24 h, reduced demand for drugs, locked or poslablyutsya eyforychni effects of opioids provided samovvedennya, and when the tend is not sensitive to the sedative effect of methadone. Analgesics. Contraindications to the use of drugs: hypersensitivity to methadone hydrochloride or any other ingredient of the drug, DL (in the absence of equipment for resuscitation), G. Opioids. Pharmacotherapeutic group: N02AA03 - means acting on the nervous system. The tend pharmaco-therapeutic effects: acting mainly on central nervous system and Level of Consciousness with smooth muscles, the main therapeutic use of methadone - analgesia, detoxification or maintenance therapy for opiate dependence, mu-agonist, a synthetic opioid analgesics with complex action, similar to the action of morphine; withdrawal with-m in the case of methadone, although this is qualitatively similar to morphine, but differs slower development, longer course and less severe symptoms, some data also indicate that methadone acts as an antagonist at the receptor N-methyl-D -aspartat (NMDA), but NMDA-receptors participate in the therapeutic effectiveness of methadone is not known. 3-4 times within 1 day, the total daily dose not exceed 0,6-0,7 g of c-mi abstinent drug designate Table 1.
